https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:279 8,000 infections and > 700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.]]> Wed 11 Apr 2018 11:07:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34629 Wed 09 Feb 2022 15:57:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50715 Wed 02 Aug 2023 16:17:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38038 Tue 27 Jul 2021 14:49:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26559 Thu 17 Feb 2022 09:28:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8095 Sat 24 Mar 2018 08:39:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22172 Sat 24 Mar 2018 07:14:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23403 Mon 19 Aug 2024 09:48:18 AEST ]]>